Journal article
Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis
R Kumar, PT Bunn, SS Singh, SS Ng, M Montes de Oca, F De Labastida Rivera, SB Chauhan, N Singh, RJ Faleiro, CL Edwards, TCM Frame, M Sheel, RJ Austin, SW Lane, T Bald, MJ Smyth, GR Hill, SE Best, A Haque, D Corvino Show all
Cell Reports | CELL PRESS | Published : 2020
Abstract
CD4+ T cells are critical for control of intracellular parasites such as Leishmania donovani. Kumar et al. show that type I interferons (IFNs) suppress Th1 cells and promote IL-10-producing CD4+ T cells during visceral leishmaniasis (VL). Thus, manipulation of type I IFN signaling may improve disease outcome in VL patients.
Grants
Awarded by National Institutes of Health
Funding Acknowledgements
We thank the staff at the Kala-Azar Medical Research Centre (KAMRC), Muzaffarpur, Bihar, India for help with collecting blood samples as well as patients and volunteers for allowing use of blood samples. We thank the staff at the QIMR Berghofer flow cytometry laboratory for assistance and the staff at the QIMR animal facility for animal husbandry. We thank the NIH tetramer facility (Atlanta, GA) for production of the I-A<SUP>b</SUP>-PEPCK<INF>335-351</INF> tetramer used to detect L. donovani PEPCK-specific CD4<SUP>+</SUP> T cells in these studies. This work was made possible through NIH Tropical Medicine Research Centers (TMRC) grant U19 AI074321 and Queensland State Government funding. The research was supported by grants and fellowships from the National Health and Medical Research Council of Australia (NHMRC; 1037304, 1058685, 1132975, and 1154265) as well as Australian post-graduate awards through Griffith University Institute of Glycomics and School of Natural Sciences (to P.B. and S.S.N., respectively), junior research fellowships from the Indian Council of Medical Research (to S.S.S. and S.B.C.), and an INSPIRE Faculty fellowship (LBSM-109/IF-14 to R.K.) provided by the Indian government Department of Science and Technology (DST).